Chromothripsis

نویسندگان

  • Emily M. Hatch
  • Martin W. Hetzer
چکیده

to determine whether C is part of the mechanism by which A contributes to B. Biologists use convergency and consistency amongst these experiments to judge the strength of any causal assertion. Therefore, in research maps convergency and consistency amongst results increases the score assigned to each edge, while contradictory results have the opposite effect. By selecting any one edge in a particular research map, users can be directed to the exact experiments and associated research papers represented by that edge. Of course, there is much more to researchmaps, but this gives you a sense of what these maps are all about.

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Massive genomic rearrangements, a result of single catastrophic event termed chromothrispsis or chromosomal catastrophe, have been identified in a variety of human cancers. In a few cancer types, chromothripsis was found to be associated with poor prognosis. We performed mate-pair sequencing and analysis of structural rearrangements in 132 prostate cancer cases which included clinically insigni...

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In Brief: Chromothripsis and cancer.

Chromothripsis is a one-step catastrophic event which plays an important role during cancer development. During chromothripsis, tens to hundreds of genomic rearrangements can occur within localized regions of the genome, and lead to the simultaneous creation of multiple cancer-driving aberrations. Given that chromothripsis has a cancer-wide incidence of 2-3%, its recent discovery has significan...

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Criteria for Inference of Chromothripsis in Cancer Genomes

Chromothripsis scars the genome when localized chromosome shattering and repair occurs in a one-off catastrophe. Outcomes of this process are detectable as massive DNA rearrangements affecting one or a few chromosomes. Although recent findings suggest a crucial role of chromothripsis in cancer development, the reproducible inference of this process remains challenging, requiring that cataclysmi...

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Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, progression and developing of metastases. The aim of this study was to evaluate the effect of chromot...

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The elusive evidence for chromothripsis

The chromothripsis hypothesis suggests an extraordinary one-step catastrophic genomic event allowing a chromosome to 'shatter into many pieces' and reassemble into a functioning chromosome. Recent efforts have aimed to detect chromothripsis by looking for a genomic signature, characterized by a large number of breakpoints (50-250), but a limited number of oscillating copy number states (2-3) co...

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عنوان ژورنال:
  • Current Biology

دوره 25  شماره 

صفحات  -

تاریخ انتشار 2015