Chromothripsis
نویسندگان
چکیده
to determine whether C is part of the mechanism by which A contributes to B. Biologists use convergency and consistency amongst these experiments to judge the strength of any causal assertion. Therefore, in research maps convergency and consistency amongst results increases the score assigned to each edge, while contradictory results have the opposite effect. By selecting any one edge in a particular research map, users can be directed to the exact experiments and associated research papers represented by that edge. Of course, there is much more to researchmaps, but this gives you a sense of what these maps are all about.
منابع مشابه
Bat flight
dramatically between cancer types. However, the question of whether these differences represent changes in the frequency of chromothripsis between different cell types or changes in the ability of different cell types to survive chromothripsis remains unclear. Finally, additional work will be required to identify the time at which chromothripsis occurs. The micronucleus model of chromothripsis ...
متن کاملChromosomal catastrophe is a frequent event in clinically insignificant prostate cancer
Massive genomic rearrangements, a result of single catastrophic event termed chromothrispsis or chromosomal catastrophe, have been identified in a variety of human cancers. In a few cancer types, chromothripsis was found to be associated with poor prognosis. We performed mate-pair sequencing and analysis of structural rearrangements in 132 prostate cancer cases which included clinically insigni...
متن کاملIn Brief: Chromothripsis and cancer.
Chromothripsis is a one-step catastrophic event which plays an important role during cancer development. During chromothripsis, tens to hundreds of genomic rearrangements can occur within localized regions of the genome, and lead to the simultaneous creation of multiple cancer-driving aberrations. Given that chromothripsis has a cancer-wide incidence of 2-3%, its recent discovery has significan...
متن کاملCriteria for Inference of Chromothripsis in Cancer Genomes
Chromothripsis scars the genome when localized chromosome shattering and repair occurs in a one-off catastrophe. Outcomes of this process are detectable as massive DNA rearrangements affecting one or a few chromosomes. Although recent findings suggest a crucial role of chromothripsis in cancer development, the reproducible inference of this process remains challenging, requiring that cataclysmi...
متن کاملChromothripsis and progression-free survival in metastatic colorectal cancer
Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, progression and developing of metastases. The aim of this study was to evaluate the effect of chromot...
متن کاملThe elusive evidence for chromothripsis
The chromothripsis hypothesis suggests an extraordinary one-step catastrophic genomic event allowing a chromosome to 'shatter into many pieces' and reassemble into a functioning chromosome. Recent efforts have aimed to detect chromothripsis by looking for a genomic signature, characterized by a large number of breakpoints (50-250), but a limited number of oscillating copy number states (2-3) co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current Biology
دوره 25 شماره
صفحات -
تاریخ انتشار 2015